Abstract
Background
In foot and ankle infections, cases with apparent soft-tissue necrosis or purulent fluid collections definitely require surgical treatments. However, clinicians often have difficulty in determining whether to perform surgery in ambiguous cases without these findings. This study aimed to investigate the impact of the delta neutrophil index as a predictor of surgical treatment in patients with foot and ankle infections.
Methods
In total, 66 patients diagnosed with foot and ankle infections who underwent the delta neutrophil index test were retrospectively investigated. Medical records, including data on diabetes mellitus status, delta neutrophil index values, white blood cell count, polymorphonuclear leukocyte count, erythrocyte sedimentation rate, and C-reactive protein level, were retrospectively investigated. Logistic regression models were analyzed for the correlation between biomarkers, such as the delta neutrophil index and surgical treatment. The area under the curve was investigated to evaluate the cut-off value of the logistic model in predicting surgery.
Results
The relationship between the delta neutrophil index and surgical treatment was analyzed. The delta neutrophil index, adjusted for diabetes mellitus, was the best predictor of future surgical intervention. Based on the Youden index, the cutoff point (the equation’s adjusted by diabetes mellitus) for the prediction of surgical treatment was defined as a probability of 0.3, with sensitivity and specificity of 82.4% and 77.6%, respectively.
Conclusions
Based on the present study, the delta neutrophil index can help clinicians decide the appropriate surgical treatment for foot and ankle infections at the right time.
Publisher
Public Library of Science (PLoS)
Reference32 articles.
1. National Hospital Ambulatory Medical Care Survey: 2006 emergency department summary;SR Pitts;National health statistics reports; no 7,2008
2. Foot and ankle infections: diagnosis and management;OA Anakwenze;JAAOS-Journal of the American Academy of Orthopaedic Surgeons,2012
3. Delta neutrophil index levels can be a good indicator to predict patients with chronic rhinosinusitis who need surgery;S Son;Ear, Nose & Throat Journal,2021
4. Delta neutrophil index (DNI) as a novel diagnostic and prognostic marker of infection: a systematic review and meta-analysis;JH Park;Inflammation Research,2017
5. Circulating neutrophil counts and mortality in septic shock;JF Bermejo-Martín;Critical Care,2014
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