Identification of COVID-19 spread mechanisms based on first-wave data, simulation models, and evolutionary algorithms

Abstract

Background The COVID-19 epidemic has shown that efficient prediction models are required, and the well-known SI, SIR, and SEIR models are not always capable of capturing the real dynamics. Modified models with novel structures could help identify unknown mechanisms of COVID-19 spread. Objective Our objective is to provide additional insights into the COVID-19 spread mechanisms based on different models’ parameterization which was performed using evolutionary algorithms and the first-wave data. Methods Data from the Our World in Data COVID-19 database was analysed, and several models—SI, SIR, SEIR, SEIUR, and Bass diffusion—and their variations were considered for the first wave of the COVID-19 pandemic. The models’ parameters were tuned with differential evolution optimization method L-SHADE to find the best fit. The algorithm for the automatic identification of the first wave was developed, and the differential evolution was applied to model parameterization. The reproduction rates (R0) for the first wave were calculated for 61 countries based on the best fits. Results The performed experiments showed that the Bass diffusion model-based modification could be superior compared to SI, SIR, SEIR and SEIUR due to the component responsible for spread from an external factor, which is not directly dependent on contact with infected individuals. The developed modified models containing this component were shown to perform better when fitting to the first-wave cumulative infections curve. In particular, the modified SEIR model was better fitted to the real-world data than the classical SEIR in 43 cases out of 61, based on Mann–Whitney U tests; the Bass diffusion model was better than SI for 57 countries. This showed the limitation of the classical models and indicated ways to improve them. Conclusions By using the modified models, the mechanism of infection spread, which is not directly dependent on contacts, was identified, which significantly influences the dynamics of the spread of COVID-19.