High baseline body mass index predicts recovery of CD4+ T lymphocytes for HIV/AIDS patients receiving long-term antiviral therapy

Author:

Zhu JiawenORCID,Huang Haimei,Wang Min,Zhang Yun,Mo Jinli,Tian Weiyi,Tan Sumin,Jiang Li,Meng Zhihao,Qin Shanfang,Ning ChuanyiORCID

Abstract

The relationship between baseline BMI and CD4+ T cells during follow-up in HIV patients in China requires further evaluation. We conducted a retrospective cohort study based on adult AIDS patients who underwent or received antiretroviral therapy from 2003 to 2019 in Guangxi, China. BMI was divided into categories and compared, and after adjusting for BMI being related to the change in CD4 lymphocyte count, with normal weight as the reference group, the BMI before treatment was positively correlated with the changes in CD4+ T cells at different time periods. Among them, obese patients had significant CD4+ cell gain. In patients with pretreatment CD4+ T lymphocyte counts <200 cells/μL, a higher BMI was associated with an increased likelihood of achieving immunologic reconstitution [≥350 cells/μL: AHR: 1.02(1.01, 1.04), P = 0.004; ≥500 cells/μL: AHR: 1.03 (1.01, 1.05), P = 0.004]. Underweight in HIV patients was a risk factor for poor viral suppression [AHR: 1.24 (1.04, 1.48), P = 0.016]. Our study demonstrated that HIV/AIDS patients receiving ART with higher baseline BMI had better immune reconstitution and that baseline BMI could be an important predictor of immune reconstitution in patients receiving ART. Baseline BMI was not associated with virological failure, but a lower baseline BMI indicated poor viral suppression during follow-up.

Funder

the National Natural Science Foundation of China

the Natural Science Foundation of Guangxi

the “Thirteenth Five-Year” National Major Science and Technology Projects

the Innovation Project of Guangxi Graduate Education

the Opening topic fund of Guangxi Key Laboratory of AIDS Prevention and Treatment

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

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