Abstract
Background
Information on the long-term pulmonary sequelae following SARS-CoV-2 infection is limited.
Methods
Prospective cohort study of hospitalized and non-hospitalized adult patients age >18 with documented SARS-CoV-2 infection by RT-PCR three months prior to enrolment between June and December 2020. Participants underwent full pulmonary function test (PFT), cardiopulmonary exercise testing at 3 months and 6 months. Primary outcome was mean differences of forced vital capacity (FVC), diffuse capacity of lung for carbon monoxide (DLCO), and oxygen consumption (VO2) at 6 vs. 3 months. Secondary outcomes were respiratory outcomes classified into 5 clinical groups–no lung disease, resolved lung disease, persistent lung disease, PFT abnormalities attributable to pre-existing lung disease or other factors, and mild PFT abnormalities of uncertain clinical significance.
Results
Fifty-one, 30 hospitalized and 21 non-hospitalized, participants were included. Median age was 51 years; 20 (39.2%) were female. Mean (±SD) percent predicted values of FVC, DLCO and VO2 at 3 vs 6-month-visits were 96.2 ± 15.6 vs. 97.6 ± 15.5, 73.74 ±18 vs. 78.5 ± 15.5, and 75.5 ± 18.9 vs. 76.1 ± 21.5, respectively. Nineteen (37%) patients had physiologic and/or radiographic evidence of lung disease at 3 months with eight (15.7%) continuing to have persistent disease at 6 months. History of diabetes, hypertension, ICU admission and elevated D-Dimer levels were associated with persistent lung disease at 6 months.
Interpretation
Persistent lung disease at 6 months post SARS-CoV-2 infection exists. Changes of lung function between 3- and 6-months are not significant. A longer follow-up is required to determine long-term prognosis.
Funder
Ottawa Hospital COVID-19 Emergency Response Fund
Publisher
Public Library of Science (PLoS)
Reference12 articles.
1. SARS-CoV-2 viral load in upper respiratory specimens of infected patients;L Zou;New England Journal of Medicine. Massachusetts Medical Society,2020
2. Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations [Internet]. [cited 2020 Jul 14]. Available from: https://www.who.int/news-room/commentaries/detail/modes-of-transmission-of-virus-causing-covid-19-implications-for-ipc-precaution-recommendations.
3. Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19).;F Jiang;Journal of General Internal Medicine,2020
4. The epidemiology and clinical information about COVID-19;H Ge;European Journal of Clinical Microbiology and Infectious Diseases,2020
5. Nalbandian A, Sehgal K, Gupta A, Madhavan M V, McGroder C, Stevens JS, et al. Post-acute COVID-19 syndrome. Nat Med [Internet]. Available from: https://doi.org/10.1038/s41591-021-01283-z.
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