Low levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability

Author:

Zago Michela,Sheridan Jared A.,Traboulsi Hussein,Hecht Emelia,Zhang Yelu,Guerrina Necola,Matthews Jason,Nair Parameswaran,Eidelman David H.,Hamid Qutayba,Baglole Carolyn J.ORCID

Funder

Institute of Circulatory and Respiratory Health

Natural Sciences and Engineering Research Council of Canada

Canada Foundation for Innovation

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference44 articles.

1. Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung;U Lappalainen;Am J Respir Cell Mol Biol,2005

2. Cyclooxygenase-2 is up-regulated in lung parenchyma of chronic obstructive pulmonary disease and down-regulated in idiopathic pulmonary fibrosis;A Xaubet;Sarcoidosis Vasc Diffuse Lung Dis,2004

3. Anti-inflammatory effects of celecoxib in rat lungs with smoke-induced emphysema;GS Roh;Am J Physiol Lung Cell Mol Physiol,2010

4. Aryl Hydrocarbon Receptor-Dependent Retention of Nuclear HuR Suppresses Cigarette Smoke-Induced Cyclooxygenase-2 Expression Independent of DNA-Binding;M Zago;PLoS One,2013

5. AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines;SL Hockley;Chem Res Toxicol,2007

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