Sieve analysis of breakthrough HIV-1 sequences in HVTN 505 identifies vaccine pressure targeting the CD4 binding site of Env-gp120

Author:

deCamp Allan C.ORCID,Rolland Morgane,Edlefsen Paul T.,Sanders-Buell Eric,Hall Breana,Magaret Craig A.,Fiore-Gartland Andrew J.,Juraska Michal,Carpp Lindsay N.,Karuna Shelly T.,Bose Meera,LePore Steven,Miller Shana,O'Sullivan Annemarie,Poltavee Kultida,Bai Hongjun,Dommaraju Kalpana,Zhao Hong,Wong Kim,Chen Lennie,Ahmed Hasan,Goodman Derrick,Tay Matthew Z.,Gottardo Raphael,Koup Richard A.,Bailer Robert,Mascola John R.,Graham Barney S.,Roederer Mario,O’Connell Robert J.,Michael Nelson L.,Robb Merlin L.,Adams Elizabeth,D’Souza Patricia,Kublin James,Corey Lawrence,Geraghty Daniel E.,Frahm Nicole,Tomaras Georgia D.,McElrath M. Juliana,Frenkel Lisa,Styrchak Sheila,Tovanabutra Sodsai,Sobieszczyk Magdalena E.,Hammer Scott M.,Kim Jerome H.,Mullins James I.,Gilbert Peter B.

Funder

NIAID and the US Army Medical Research and Material Command

National Institute of Allergy and Infectious Diseases

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference59 articles.

1. UNAIDS. The GAP Report. 2014.

2. Centers for Disease Control and Prevention. Today's HIV/AIDS Epidemic. CDC [Internet]. 2014 2/11/2015. Available from: http://www.cdc.gov/nchhstp/newsroom/docs/hivfactsheets/todaysepidemic-508.pdf.

3. Ten years after Dublin: principal trends in HIV surveillance in the EU/EEA, 2004 to 2013;A Pharris;Euro Surveill,2014

4. Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection;NM Flynn;J Infect Dis,2005

5. Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand;P Pitisuttithum;J Infect Dis,2006

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