Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor

Author:

Gorelenkova Miller Olga,Cole Kyle S.,Emerson Corey C.,Allimuthu Dharmaraja,Golczak Marcin,Stewart Phoebe L.,Weerapana Eranthie,Adams Drew J.,Mieyal John J.ORCID

Funder

National Institutes of Health

National Institute of Neurological Disorders and Stroke

U.S. Department of Veterans Affairs

National Institute of General Medical Sciences

Ohio Supercomputer Center

National Eye Institute

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference43 articles.

1. Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases;O Gorelenkova Miller;Archives of toxicology,2015

2. Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases;MD Shelton;Mol Cells,2008

3. Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation;MM Gallogly;Antioxidants & redox signaling,2009

4. Ablation of glutaredoxin-1 attenuates lipopolysaccharide-induced lung inflammation and alveolar macrophage activation;SW Aesif;American journal of respiratory cell and molecular biology,2011

5. Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Muller cells: model of diabetic retinopathy;MD Shelton;The Journal of biological chemistry,2007

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