Production of proinflammatory mediators in activated microglia is synergistically regulated by Notch-1, glycogen synthase kinase (GSK-3β) and NF-κB/p65 signalling

Author:

Cao Qiong,Karthikeyan Aparna,Dheen S. Thameem,Kaur Charanjit,Ling Eng-AngORCID

Funder

National University of Singapore.

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference33 articles.

1. Microglial activation and its implications in the brain diseases;ST Dheen;Curr Med Chem,2007

2. Dexamethasone suppresses MCP-1 production via MAP kinase phosphatase-1 dependent inhibition of JNK and p38 MAPK in activated rat microglia;Y Zhou;J Neurochem,2007

3. Nuclear factor-κB/p65 responds to changes in the Notch signalling pathway in murine BV-2 cells and in amoeboid microglia in postnatal rats treated with the γ-secretase complex blocker DAPT;Q Cao;J Neurosci Res,2010

4. Glycogen synthase kinase 3 is part of the molecular machinery regulating the adaptive response to LPS stimulation in microglial cells;MA Ajmone-Cat;Brain Behav Immun,2016

5. Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens;R Cortés-Vieyra;J Inflamm,2012

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