TNFα/IFNγ Mediated Intestinal Epithelial Barrier Dysfunction Is Attenuated by MicroRNA-93 Downregulation of PTK6 in Mouse Colonic Epithelial Cells

Author:

Haines Ricci J.ORCID,Beard Richard S.,Eitner Rebecca A.,Chen Liwei,Wu Mack H.

Funder

National Institutes of Health

U.S. Department of Veterans Affairs

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference38 articles.

1. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms;M Bruewer;Journal of immunology,2003

2. Identification of β-catenin as a target of the intracellular tyrosine kinase PTK6;HL Palka-Hamblin;J Cell Sci,2010

3. Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin;A Youakim;The American journal of physiology,1999

4. Superantigen activation of immune cells evokes epithelial (T84) transport and barrier abnormalities via IFN-gamma and TNF alpha: inhibition of increased permeability, but not diminished secretory responses by TGF-beta2;DM McKay;Journal of immunology,1997

5. Amelioration of IFN-gamma and TNF-alpha-induced intestinal epithelial barrier dysfunction by berberine via suppression of MLCK-MLC phosphorylation signaling pathway;M Cao;PloS one,2013

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