Sensitive Detection of Pre-Existing BCR-ABL Kinase Domain Mutations in CD34+ Cells of Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia Patients Is Associated with Imatinib Resistance: Implications in the Post-Imatinib Era

Author:

Iqbal Zafar,Aleem Aamer,Iqbal Mudassar,Naqvi Mubashar Iqbal,Gill Ammara,Taj Abid Sohail,Qayyum Abdul,ur-Rehman Najeeb,Khalid Ahmad Mukhtar,Shah Ijaz Hussain,Khalid Muhammad,Haq Riazul,Khan Mahwish,Baig Shahid Mahmood,Jamil Abid,Abbas Muhammad Naeem,Absar Muhammad,Mahmood Amer,Rasool Mahmood,Akhtar Tanveer

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference46 articles.

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3. Kantarjian H, Cortes J (2008) BCR-ABL tyrosine kinase inhibitors in chronic myeloid leukemia: using guidelines to make rational treatment choices. J Natl Compr Canc Netw Suppl 2: S37–S42; quiz S43–S44.

4. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification;ME Gorre;Science,2001

5. GIMEMA Working Party on Chronic Myeloid Leukemia. Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia-positive patients: by the GIMEMA Working Party on Chronic Myeloid Leukemia;S Soverini;Clin Cancer Res,2006

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