R-Spondin Potentiates Wnt/β-Catenin Signaling through Orphan Receptors LGR4 and LGR5

Author:

Ruffner Heinz,Sprunger Joëlle,Charlat Olga,Leighton-Davies Juliet,Grosshans Bianka,Salathe Adrian,Zietzling Svenja,Beck Valérie,Therier Maxime,Isken Andrea,Xie Yang,Zhang Yue,Hao Huaixiang,Shi Xiaoying,Liu Dong,Song Qinhui,Clay Ieuan,Hintzen Gabriele,Tchorz Jan,Bouchez Laure C.,Michaud Gregory,Finan Peter,Myer Vic E.,Bouwmeester Tewis,Porter Jeff,Hild Marc,Bassilana Fred,Parker Christian N.,Cong Feng

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference40 articles.

1. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17: 9–26.;BT MacDonald,2009

2. Wnt/beta-catenin signaling in development and disease.;H Clevers;Cell,2006

3. R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell 19: 2588–2596.;KA Kim,2008

4. R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell 7: 525–534.;O Kazanskaya,2004

5. Mitogenic influence of human R-spondin1 on the intestinal epithelium. Science 309: 1256–1259.;KA Kim,2005

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