Restoration of Corticosteroid Sensitivity by p38 Mitogen Activated Protein Kinase Inhibition in Peripheral Blood Mononuclear Cells from Severe Asthma

Author:

Mercado Nicolas,Hakim Amir,Kobayashi Yoshiki,Meah Sally,Usmani Omar S.,Chung Kian Fan,Barnes Peter J.,Ito Kazuhiro

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference47 articles.

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2. Lung Function in Adults with Stable but Severe Asthma: Air Trapping and Incomplete Reversal of Obstruction with Bronchodilation.;RL Sorkness,2007

3. Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society.;KF Chung;Eur Respir J,1999

4. Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma.;M Hew;Am J Respir Crit Care Med,2006

5. p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma.;E Irusen;J Allergy Clin Immunol,2002

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