The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes

Author:

Hayward Catherine P. M.ORCID,Liang Minggao,Tasneem Subia,Soomro Asim,Waye John S.,Paterson Andrew D.,Rivard Georges E.,Wilson Michael D.

Funder

Institute of Circulatory and Respiratory Health

Heart and Stroke Foundation of Canada

Heart and Stroke Foundation of Ontario

Natural Sciences and Engineering Research Council of Canada

Restracomp trainee scholarship

Canada Research Chairs

Faculty of Health Sciences

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference49 articles.

1. Failure of thrombus to resolve in urokinase-type plasminogen activator gene-knockout mice: rescue by normal bone marrow-derived cells;I Singh;Circulation,2003

2. Polymorphonuclear leucocytes mediate endogenous thrombus lysis via a u-PA-dependent mechanism;E Moir;British journal of haematology,2001

3. Localization and identification of thrombin and plasminogen activator activities in model human thrombi by in situ zymography;NJ Mutch;Thromb Haemost,2002

4. Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase-type plasminogen activator;WH Kahr;Blood,2001

5. Quebec platelet disorder;CP Hayward;Expert review of hematology,2011

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