A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5-Reference-Cited by-同舟云学术

A consistent and potentially exploitable response during chondrogenesis of mesenchymal stem cells from osteoarthritis patients to the protein encoded by the susceptibility gene GDF5

Published:2017-05-08 Issue:5 Volume:12 Page:e0176523
ISSN:1932-6203
Container-title:PLOS ONE
language:en
Short-container-title:PLoS ONE

Author:

Ratnayake Madhushika,Tselepi Maria,Bloxham Robert,Plöger Frank,Reynard Louise N.,Loughlin John^ORCID

Funder

Arthritis Research UK

Seventh Framework Programme

Medical Research Council

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference21 articles.

1. A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis;Y Miyamoto;Nat Genet,2007

2. An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage;L Southam;Hum Mol Genet,2007

3. CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis SNP rs143383;LN Reynard;Hum Genet,2014

4. GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signalling inhibition;L Enochson;Osteoarthritis Cartilage,2014

5. Mechanisms of GDF-5 action during skeletal development;PH Francis-West;Development,1999

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