Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin

Author:

Niego Be’eriORCID,Lee Natasha,Larsson Pia,De Silva T. Michael,Au Amanda E-Ling,McCutcheon Fiona,Medcalf Robert L.

Funder

National Heart Foundation of Australia

National Health and Medical Research Council

Foundation for High Blood Pressure Research

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference53 articles.

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2. Complications associated with recombinant tissue plasminogen activator therapy for acute ischaemic stroke;JS Balami;CNS & neurological disorders drug targets,2013

3. Symptomatic intracerebral hemorrhage in acute ischemic stroke after thrombolysis with intravenous recombinant tissue plasminogen activator: a review of natural history and treatment;S Yaghi;JAMA neurology,2014

4. Tissue plasminogen activator in central nervous system physiology and pathology;JP Melchor;Thrombosis and haemostasis,2005

5. Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function;AL Samson;Journal of neurochemistry,2008

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