Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism

Author:

Roomp Kirsten,Kristinsson HjaltiORCID,Schvartz Domitille,Ubhayasekera Kumari,Sargsyan Ernest,Manukyan Levon,Chowdhury Azazul,Manell Hannes,Satagopam Venkata,Groebe Karlfried,Schneider Reinhard,Bergquist Jonas,Sanchez Jean-Charles,Bergsten Peter

Funder

European Commission FP7-project

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference49 articles.

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3. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study;BC Martin;Lancet,1992

4. FFAR1 is involved in both the acute and chronic effects of palmitate on insulin secretion;H Kristinsson;Endocrinology,2013

5. Initial hyperinsulinemia and subsequent beta-cell dysfunction is associated with elevated palmitate levels;J Staaf;Pediatric research,2016

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