Genomic variants reveal differential evolutionary constraints on human transglutaminases and point towards unrecognized significance of transglutaminase 2

Author:

Thangaraju Kiruphagaran,Király Róbert,Demény Máté A.,András Mótyán János,Fuxreiter Mónika,Fésüs László

Funder

Research grant of the University of Debrecen

Országos Tudományos Kutatási Alapprogramok

New Hungary Development Plan

European Union Framework Programme 7 TRANSPATH ITN

European Union and the State of Hungary, co-financed by the European Social Fund

Momentum program of the Hungarian Academy of Sciences

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference85 articles.

1. Transglutaminase 2: an enigmatic enzyme with diverse functions;L Fesus;Trends Biochem Sci,2002

2. Transglutaminases: crosslinking enzymes with pleiotropic functions;L Lorand;Nature Reviews Molecular Cell Biology,2003

3. Transglutaminases. Multiple functional modifiers and targets for new drug discovery;MA Demény,2015

4. Physiological, pathological, and structural implications of nonenzymatic protein–protein interactions of the multifunctional human transglutaminase 2;K Kanchan;Cell Mol Life Sci,2015

5. Transglutaminase regulation of cell function;RL Eckert;Physiol Rev,2014

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