Prevalence and risk factors of early postoperative seizures in patients with glioma: A protocol for meta-analysis and systematic review

Abstract

Introduction Early postoperative seizures has been the most common clinical expression in gliomas; however, the incidence and risk factors for early postoperative seizures in gliomas are more controversial. This protocol describes a systematic review and meta-analysis to clarify the prevalence and risk factors of early postoperative seizures in patients with glioma. Methods and analysis Searches will be conducted on CNKI, WanFang, VIP, PubMed, Embase, Cochrane Library databases and Web of Science for the period from database inception to December 31st, 2023. Case-control and cohort studies of the incidence and risk factors for early postoperative seizures in all gliomas will be included. The primary outcome will be incidence, risk factors. Newcastle-Ottawa Scale was used for quality evaluation. Review of article screening, extracting data and risk of bias assessment will be repeated by two independent reviewers. Result This study will provide evidence for the risk factors and incidence of early postoperative seizures in patients with glioma. Conclusion Our study will provide evidence for the prevention of early postoperative seizures in glioma patients. Trail registration This protocol was registered in PROSPERO and registration number is CRD42023415658.