Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA-Reference-Cited by-同舟云学术

Nascent mutant Huntingtin exon 1 chains do not stall on ribosomes during translation but aggregates do recruit machinery involved in ribosome quality control and RNA

Published:2020-07-31 Issue:7 Volume:15 Page:e0233583
ISSN:1932-6203
Container-title:PLOS ONE
language:en
Short-container-title:PLoS ONE

Author:

Ormsby Angelique R.,Cox Dezerae^ORCID,Daly James,Priest David,Hinde Elizabeth,Hatters Danny M.^ORCID

Funder

National Health and Medical Research Council

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

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3. RNA toxicity induced by expanded CAG repeats in Huntington's disease;E. Martí;Brain Pathol,2016

4. Huntingtin-encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo;E Scherzinger;Cell,1997

5. Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain;M DiFiglia;Science,1997

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1. RNA recruitment switches the fate of protein condensates from autophagic degradation to accumulation;Journal of Cell Biology;2023-04-04

2. The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity;Nature Structural & Molecular Biology;2023-03

3. Update Advances in Ribosome-associated Quality Control and Ribophagy br;PROG BIOCHEM BIOPHYS;2022

4. RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration;Frontiers in Genetics;2022-05-12

5. Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease;Nature Communications;2021-03-05