A polymorphism in the cachexia-associated gene INHBA predicts efficacy of regorafenib in patients with refractory metastatic colorectal cancer

Author:

Miyamoto YujiORCID,Schirripa Marta,Suenaga MitsukuniORCID,Cao Shu,Zhang Wu,Okazaki Satoshi,Berger Martin D.,Matsusaka Satoshi,Yang Dongyun,Ning Yan,Baba Hideo,Loupakis Fotios,Lonardi Sara,Pietrantonio Filippo,Borelli Beatrice,Cremolini Chiara,Yamaguchi Toshiharu,Lenz Heinz-Josef

Funder

Foundation for the National Institutes of Health

the Gloria Borges Wunderglo Project

Dhont Family Foundation

Daniel Butler Research Fundation

Call to Cure Research Fundation

Japan Society for the Promotion of Science

Takashi Tsuruo Memorial Fundation

Werner and Hedy Berger-Janser Foundation

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference49 articles.

1. Regorafenib (BAY 73–4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity;SM Wilhelm;Int J cancer,2011

2. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicentre, randomised, placebo-controlled, phase 3 trial;A Grothey;Lancet,2013

3. Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): A randomised, double-blind, placebo-controlled, phase 3 trial;J Li;Lancet Oncol,2015

4. Network NCC. National Comprehensive Cancer Network (NCCN). Guidel Version 1 2016 Colon Cancer. 2016. Available: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001308/

5. ESMO consensus guidelines for the management of patients with metastatic colorectal cancer;E Van Cutsem;Ann Oncol,2016

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