The promiscuous enzyme medium-chain 3-keto-acyl-CoA thiolase triggers a vicious cycle in fatty-acid beta-oxidation

Author:

Martines Anne-Claire M. F.ORCID,van Eunen Karen,Reijngoud Dirk-Jan,Bakker Barbara M.ORCID

Funder

Universitair Medisch Centrum Groningen

Rosalind Franklin Fellowship, University of Groningen (NL)

NWO grant (Centers for Systems Biology Research programme) (NL)

Top Institute for Food and Nutrition (NL)

Publisher

Public Library of Science (PLoS)

Subject

Computational Theory and Mathematics,Cellular and Molecular Neuroscience,Genetics,Molecular Biology,Ecology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics

Reference55 articles.

1. Fatty Acid oxidation Disorders;P Rinaldo;Annu Rev Physiol,2002

2. The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders;SM Houten;Annu Rev Physiol,2016

3. The natural history of medium-chain acyl CoA dehydrogenase deficiency in the Netherlands: Clinical presentation and outcome;TGJ Derks;J Pediatr,2006

4. Neonatal screening for medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in The Netherlands: The importance of enzyme analysis to ascertain true MCAD deficiency;TGJ Derks;J Inherit Metab Dis,2008

5. In vitro and in vivo consequences of variant medium-chain acyl-CoA dehydrogenase genotypes;CML Touw;Orphanet J Rare Dis,2013

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