Systems-Wide Prediction of Enzyme Promiscuity Reveals a New Underground Alternative Route for Pyridoxal 5’-Phosphate Production in E. coli-Reference-Cited by-同舟云学术

Systems-Wide Prediction of Enzyme Promiscuity Reveals a New Underground Alternative Route for Pyridoxal 5’-Phosphate Production in E. coli

Published:2016-01-28 Issue:1 Volume:12 Page:e1004705
ISSN:1553-7358
Container-title:PLOS Computational Biology
language:en
Short-container-title:PLoS Comput Biol

Author:

Oberhardt Matthew A.,Zarecki Raphy,Reshef Leah,Xia Fangfang,Duran-Frigola Miquel,Schreiber Rachel,Henry Christopher S.,Ben-Tal Nir,Dwyer Daniel J.,Gophna Uri,Ruppin Eytan

Publisher

Public Library of Science (PLoS)

Subject

Computational Theory and Mathematics,Cellular and Molecular Neuroscience,Genetics,Molecular Biology,Ecology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics

Reference42 articles.

1. The Key-Lock Theory and the Induced Fit Theory;DE Koshland;Angew Chem Int Edit,1994

2. Protein dynamism and evolvability;N Tokuriki;Science,2009

3. Network context and selection in the evolution to enzyme specificity;H Nam;Science,2012

4. Glycerol dehydrogenase plays a dual role in glycerol metabolism and 2,3-butanediol formation in Klebsiella pneumoniae;Y Wang;J Biol Chem,2014

5. Antibody multispecificity mediated by conformational diversity;LC James;Science,2003

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