Allosteric modulation of cardiac myosin dynamics by omecamtiv mecarbil

Author:

Hashem ShaimaORCID,Tiberti Matteo,Fornili AriannaORCID

Funder

British Heart Foundation

Publisher

Public Library of Science (PLoS)

Subject

Computational Theory and Mathematics,Cellular and Molecular Neuroscience,Genetics,Molecular Biology,Ecology,Modelling and Simulation,Ecology, Evolution, Behavior and Systematics

Reference70 articles.

1. Targeting the sarcomere to correct muscle function;PM Hwang;Nat Rev Drug Discov,2015

2. Novel myosin-based therapies for congenital cardiac and skeletal myopathies;J Ochala;Journal of medical genetics

3. Small-molecule inhibitors of myosin proteins;LM Bond;Future Med Chem,2014

4. Hypertrophic and dilated cardiomyopathy: Four decades of basic research on muscle lead to potential therapeutic approaches to these devastating genetic diseases;JA Spudich;Biophys J,2014

5. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice;EM Green;Science,2016

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