Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design

Author:

You WanliORCID,Huang Yu-ming M.,Kizhake Smitha,Natarajan Amarnath,Chang Chia-en A.

Funder

National Institutes of Health

Publisher

Public Library of Science (PLoS)

Subject

Computational Theory and Mathematics,Cellular and Molecular Neuroscience,Genetics,Molecular Biology,Ecology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics

Reference96 articles.

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2. The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations;S Cantor;Proceedings of the National Academy of Sciences of the United States of America,2004

3. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints;A Sancar;Annual review of biochemistry,2004

4. Cancer susceptibility and the functions of BRCA1 and BRCA2;AR Venkitaraman;Cell,2002

5. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function;SB Cantor;Cell,2001

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