CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa

Author:

Tian Zhe-XianORCID,Yi Xue-Xian,Cho AnnaORCID,O’Gara Fergal,Wang Yi-Ping

Funder

National Natural Science Foundation of China

National Science Fund for Distinguished Young Scholars, China

State Key Laboratory of Protein and Plant Gene Research, China

Publisher

Public Library of Science (PLoS)

Subject

Virology,Genetics,Molecular Biology,Immunology,Microbiology,Parasitology

Reference71 articles.

1. Multidrug efflux in Pseudomonas aeruginosa: components, mechanisms and clinical significance;K Poole;Curr Top Med Chem,2001

2. Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms;PD Lister;Clin Microbiol Rev,2009

3. Efflux as a mechanism of resistance to antimicrobials in Pseudomonas aeruginosa and related bacteria: unanswered questions;HP Schweizer;Genet Mol Res,2003

4. Functional role of bacterial multidrug efflux pumps in microbial natural ecosystems;JL Martinez;FEMS Microbiol Rev,2009

5. Multidrug-resistance efflux pumps—not just for resistance;LJ Piddock;Nat Rev Microbiol,2006

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