Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors

Author:

Binning Jennifer M.ORCID,Smith Amber M.,Hultquist Judd F.,Craik Charles S.ORCID,Caretta Cartozo Nathalie,Campbell Melody G.,Burton Lily,La Greca Florencia,McGregor Michael J.,Ta Hai M.,Bartholomeeusen Koen,Peterlin B. Matija,Krogan Nevan J.,Sevillano Natalia,Cheng YifanORCID,Gross John D.ORCID

Funder

National Institute of General Medical Sciences

National Institutes of Health

National Institutes of Health (US)

National Institute of Allergy and Infectious Diseases

National Institute of Allergy and Infectious Diseases (US)

amfAR, The Foundation for AIDS Research

Publisher

Public Library of Science (PLoS)

Subject

Virology,Genetics,Molecular Biology,Immunology,Microbiology,Parasitology

Reference53 articles.

1. Novel targets for HIV therapy;W Greene;Antiviral Res,2008

2. Structural insights for HIV-1 therapeutic strategies targeting Vif;JD Salter;Trends in Biochemical Sciences,2014

3. Multiple ways of targeting APOBEC3-virion infectivity factor interactions for anti-HIV-1 drug development;JL Smith;Trends in Pharmacological Sciences,2009

4. Lentiviral Vif degrades the APOBEC3Z3/APOBEC3H protein of its mammalian host and is capable of cross-species activity;RS Larue;J Virol. American Society for Microbiology,2010

5. The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif;AM Sheehy;Nat Med. Nature Publishing Group,2003

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