Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but Mycobacterium tuberculosis counteracts this process via HIF-1α activation

Author:

Genoula Melanie,Marín Franco José Luis,Maio Mariano,Dolotowicz Belén,Ferreyra MalenaORCID,Milillo M. Ayelén,Mascarau RémiORCID,Moraña Eduardo José,Palmero DomingoORCID,Matteo Mario,Fuentes Federico,López Beatriz,Barrionuevo Paula,Neyrolles OlivierORCID,Cougoule Céline,Lugo-Villarino GeanncarloORCID,Vérollet Christel,Sasiain María del Carmen,Balboa LucianaORCID

Funder

Fondo para la Investigación Científica y Tecnológica

CONICET

Centre National de la Recherche Scientifique

Publisher

Public Library of Science (PLoS)

Subject

Virology,Genetics,Molecular Biology,Immunology,Microbiology,Parasitology

Reference71 articles.

1. World Health Organization. WHO | Global tuberculosis report 2019. WHO/CDS/TB/2019.15; 2019.

2. Foamy macrophages and the progression of the human tuberculosis granuloma;DG Russell;Nat Immunol,2009

3. Evolution of granulomas in lungs of mice infected aerogenically with Mycobacterium tuberculosis;PJ Cardona;Scand J Immunol,2000

4. Rationale for the histological spectrum of tuberculosis. A basis for classification;DS Ridley;Pathology,1987

5. Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeostasis promotes the foamy phenotype;V Singh;Cell Host Microbe,2012

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