Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

Author:

Tiemi Shio Marina,Eisenbarth Stephanie C.,Savaria Myriam,Vinet Adrien F.,Bellemare Marie-Josée,Harder Kenneth W.,Sutterwala Fayyaz S.,Bohle D. Scott,Descoteaux Albert,Flavell Richard A.,Olivier Martin

Publisher

Public Library of Science (PLoS)

Subject

Virology,Genetics,Molecular Biology,Immunology,Microbiology,Parasitology

Reference54 articles.

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2. Modulation of positive signaling an proinflammatory responses by hemozoin, a plasmodium metabolic waste.;M Olivier,2007

3. Malaria-specific metabolite hemozoin mediates the release of several potent endogenous pyrogens (TNF, MIP-1 alpha, and MIP-1 beta) in vitro, and altered thermoregulation in vivo.;BA Sherry;J Inflamm,1995

4. Periodic and chaotic host-parasite interactions in human malaria.;D Kwiatkowski;Proc Natl Acad Sci U S A,1991

5. NOD-like receptors (NLRs): bona fide intracellular microbial sensors.;MH Shaw;Curr Opin Immunol,2008

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