SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney

Author:

Francis Magen Ellen,Goncin UnaORCID,Kroeker Andrea,Swan CynthiaORCID,Ralph RobynORCID,Lu YaoORCID,Etzioni Athema LouiseORCID,Falzarano DarrylORCID,Gerdts Volker,Machtaler StevenORCID,Kindrachuk JasonORCID,Kelvin Alyson AnnORCID

Abstract

COVID-19 (coronavirus disease 2019) caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is a disease affecting several organ systems. A model that captures all clinical symptoms of COVID-19 as well as long-haulers disease is needed. We investigated the host responses associated with infection in several major organ systems including the respiratory tract, the heart, and the kidneys after SARS-CoV-2 infection in Syrian hamsters. We found significant increases in inflammatory cytokines (IL-6, IL-1beta, and TNF) and type II interferons whereas type I interferons were inhibited. Examination of extrapulmonary tissue indicated inflammation in the kidney, liver, and heart which also lacked type I interferon upregulation. Histologically, the heart had evidence of myocarditis and microthrombi while the kidney had tubular inflammation. These results give insight into the multiorgan disease experienced by people with COVID-19 and possibly the prolonged disease in people with post-acute sequelae of SARS-CoV-2 (PASC).

Funder

Canadian Institutes of Health Research

Nova Scotia Health Research Foundation

Genome Canada

Canada Foundation for Innovation

Innovation Saskatchewan

Ministry of Agriculture, Government of Saskatchewan

Publisher

Public Library of Science (PLoS)

Subject

Virology,Genetics,Molecular Biology,Immunology,Microbiology,Parasitology

Reference129 articles.

1. Zhuang Pinghui JW. Wuhan pneumonia: how the search for the source of the mystery illness unfolded South China Morning Post2020. Available from: https://www.scmp.com/news/china/society/article/3046233/wuhan-pneumonia-how-search-source-mystery-illness-unfolded.

2. WHO Declares COVID-19 a Pandemic.;D Cucinotta;Acta Biomed.,2020

3. COVID-19, SARS and MERS: are they closely related?;N Petrosillo;Clin Microbiol Infect,2020

4. Medicine JHU. Coronavirus Resource Center 2021. Available from: https://coronavirus.jhu.edu/.

5. The lasting misery of coronavirus long-haulers;M. Marshall;Nature,2020

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3