HLA-DR Alpha 2 Mediates Negative Signalling via Binding to Tirc7 Leading to Anti-Inflammatory and Apoptotic Effects in Lymphocytes In Vitro and In Vivo

Author:

Bulwin Grit-Carsta,Wälter Stephanie,Schlawinsky Mirko,Heinemann Thomas,Schulze Anke,Höhne Wolfgang,Krause Gerd,Kalka-Moll Wiltrud,Fraser Patricia,Volk Hans-Dieter,Löhler Jürgen,Milford Edgar L.,Utku Nalân

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference27 articles.

1. Prevention of acute allograft rejection by antibody targeting of TIRC7, a novel T cell membrane protein.;N Utku;Immunity,1998

2. Monoclonal antibody specific for TIRC7 induces donor-specific anergy and prevents rejection of cardiac allografts in mice.;Y Kumamoto;Am J Transplant,2004

3. Antibody targeting of TIRC7 results in significant therapeutic effects on in collagen-induced arthritis in mice.;N Utku;Clin Exp Immunol,2006

4. Molecular mechanisms regulating TH1 immune responses.;SJ Szabo;Annu Rev Immunol,2003

5. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response.;LH Wang;J Immunol,1999

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