Abstract
Salmonella, one of the major causes of foodborne infections, can cause bacterial foodborne illness. We investigated the serotype distribution, multidrug resistance (MDR), and β-lactamase resistance genes of human Salmonella isolates collected from clinical specimens in Guizhou, China, between 2013 and 2018. A total of 363 Salmonella isolates were collected from clinical specimens at 17 surveillance hospitals. Twenty-four serotypes were identified by sliding agglutination test. S. Enteritidis (33.9%), Salmonella 4,[5],12:i:- (24.0%), S. Typhimurium (16.3%), S. London (6.3%), and S. Derby (3.9%) were the top five serotypes. In 2018, the most common serotype changed from S. Enteritidis to S. Typhimurium. Among the 363 Salmonella isolates, 97.5% of isolates were resistant to at least one class of antimicrobial agents. For cephalosporins, ceftriaxone had the highest resistance rate of 10.5%, and cefepime and cefoxitin were 8.0% and 2.2%, respectively. Three hundred and one (82.9%) Salmonella isolates showed MDR. Salmonella 4,[5],12:i:- had the highest MDR rate with 94.2%, followed by S. London (91.3%) and S. Typhimurium (88.1%). Multidrug resistance rates of Salmonella isolates in Guizhou from 2013 to 2017 increased from 75.8% to 86.7%. Sixteen isolates (4.4%) showed extensive drug resistance. One hundred thirty-four antimicrobial resistance patterns were found. Two hundred and forty-one (66.4%) isolates carried at least one β-lactamase resistance gene. The blaTEM gene (61.2%) was the most prevalent resistant gene in all Salmonella isolates, followed by the blaCTX-M gene (6.1%) and blaOXA-1 gene (4.1%). Our findings showed that the MDR rate of Salmonella isolates from Guizhou province increased year by year. Therefore, systematic and long-term surveillance on MDR Salmonella isolates from clinical patients should be further strengthened.
Funder
Science and Technology Planning Support Project of Guizhou Province
Science and Technology Foundation Planning Project of Guizhou Province
Infectious Disease Prevention and Control Talent Base Scientific Research Team Project of Guizhou Province
Publisher
Public Library of Science (PLoS)
Reference46 articles.
1. Antimicrobial resistance and molecular genotyping of Salmonella enterica serovar Enteritidis clinical isolates from Guizhou province of Southwestern China;X Wei;Plos One,2019
2. Increased incidence of antimicrobial-resistant Nontyphoidal Salmonella infections, United States, 2004–2016;F Medalla;Emerging Infectious Disease,2021
3. EFSA-ECDC. The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals, and food in 2014. EFSA (European Food Safety Authority) and ECDC (European Centre for Disease Prevention and Control), 2016. 2016;EFSA J 14:207.
4. Estimation on disease burden of foodborne non-typhoid salmonellosis in China using literature review method;X Mao;Chinese Journal of Disease Control and prevention,2011
5. Analysis of the reported food poisoning incidents in public health emergency events surveillance system in China,2008–2010;F Chu;Chinese Journal of Food Hygiene,2012
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