Abstract
Genetically modified (GM) crops expressing insecticidal crystal proteins are widely accepted worldwide, but their commercial utilization demands comprehensive risk assessment studies. A 90-day risk assessment study was conducted on Wistar rats fed with GM maize (CEMB-413) expressing binary insect-resistant genes (cry1Ac and cry2Ab) at low (30%) and high (50%) dose along with a control diet group. The study used fifty Wistar rats randomly distributed in five treatment groups. Our study revealed that compared to controls, GM diet had no adverse effects on animal’s health, including body weight, food consumption, clinical pathological parameters, serum hormone levels and histological parameters of testes and ovaries of rats. Differences were observed in transcripts levels of fertility related genes, but these were independent of treatment with GM diet.
Publisher
Public Library of Science (PLoS)
Reference69 articles.
1. Bacillus thuringiensis and its pesticidal crystal proteins;E Schnepf;Microbiology and molecular biology reviews,1998
2. Bacillus thuringiensis crystal proteins that target nematodes;J-Z Wei;Proceedings of the National Academy of Sciences,2003
3. From microbial sprays to insect-resistant transgenic plants: history of the biospesticide Bacillus thuringiensis. A review;V. Sanchis;Agronomy for sustainable development,2011
4. James C. Global Status of Commercialized Biotech/GM Crops, 2010: Brief 42: ISAAA SEAsiaCenter; 2010.