Abstract
Prior to the age of measles vaccination, infants are believed to be protected against measles by passively transferred maternal antibodies. However, the quantity and quality of such protection have not been well established in the Indian setting. We undertook this study to characterize the transfer and decline in maternal anti-measles antibodies among infants, and determine their susceptibility to measles. In this population-based, birth-cohort study, we enrolled pregnant women and their newborn infants, from a catchment area of 30 Anganwadis in Chandigarh, India. We collected maternal blood at delivery, and infant blood samples at birth, and 3, 6, and 9 months of age. Anti-measles IgG antibodies were measured using quantitative ELISA. We assessed antibody decline using log-linear models. In total, 428 mother-infant dyads were enrolled, and data from 413 dyads were analyzed. At birth, 91.5% (95% CI: 88.8, 94.2) of infants had protective antibody levels, which declined to 26.3% (95% CI: 21.0%, 31.9) at 3 months, 3.4% (95% CI: 0.9, 5.9) at 6 months, and 2.1% (95% CI: 0.1, 4.1) at 9 months. Younger mothers transferred lower levels of antibodies to their infants. We concluded that the majority of infants are susceptible to measles as early as three months of age, much earlier than their eligibility to receive measles vaccination.
Publisher
Public Library of Science (PLoS)
Reference40 articles.
1. Progress Toward Regional Measles Elimination -Worldwide, 2000–2021;AA Minta;MMWR Morb Mortal Wkly Rep,2022
2. UNICEF. Measles cases are spiking globally. Available from: https://www.unicef.org/stories/measles-cases-spiking-globally. Accessed: 12 January 2023.
3. Centers for Disease Control and Prevention. Global Measles Outbreaks. https://www.cdc.gov/globalhealth/measles/data/global-measles-outbreaks.html (accessed February 19, 2023).
4. Massive measles outbreak threatens India’s goal to eliminate disease by 2023;G. Vaidyanathan;Nature,2022
5. Measles-Rubella Supplementary Immunization Activity Readiness Assessment—India, 2017–2018;V Gurnani;MMWR Morb Mortal Wkly Rep,2018