Abstract
ObjectiveTo characterize the drug-related problems (DRPs) in high-risk pregnant women with hypertension and gestational diabetes mellitus according to frequency, type, cause, and factors associated with their occurrence in the hospital setting.MethodologyThis is an observational, longitudinal, prospective study that included 571 hospitalized pregnant women with hypertension and gestational diabetes mellitus using at least one medication. DRPs were classified according to theClassification for Drug-Related Problems(PCNE V9.00). In addition to descriptive statistics, a univariate and multivariate logistic regression model was employed to determine the factors associated with the DRPs.ResultsA total of 873 DRPs were identified. The most frequent DRPs were related to therapeutic ineffectiveness (72.2%) and occurrence of adverse events (27.0%) and the main drugs involved were insulins and methyldopa. These were followed in the first five days of treatment by: the ineffectiveness of insulin (24.6%), associated with underdosage (12.9%) or insufficient frequency of administration (9.5%) and methyldopa associated with the occurrence of adverse reactions (40.2%) in the first 48h. Lower maternal age (OR 0.966, 95% CI 0.938–0.995, p = 0.022), lower gestational age (OR 0.966, 95% CI 0.938–0.996, p = 0.026), report of drug hypersensitivity (OR 2.295, 95% CI 1.220–4.317, p = 0.010), longer treatment time (OR 1.237, 95% CI: 1.147–1.333, p = 0.001) and number of prescribed medications (OR 1.211, 95% CI: 0.240–5.476, p = 0.001) were risk factors for occurrence of DRPs.ConclusionDRPs are frequent in pregnant women with hypertension and gestational diabetes mellitus, and they are mainly related to therapeutic ineffectiveness and the occurrence of adverse events.
Funder
National Counsel of Technological and Scientific Development
Publisher
Public Library of Science (PLoS)
Reference34 articles.
1. Anatomical and physiological alterations of pregnancy.;JM Kazma;J Pharmacokinet Pharmacodyn,2020
2. The Association Between High Hemoglobin Levels and Pregnancy Complications, Gestational Diabetes and Hypertension, Among Palestinian Women.;H Abumohsen;Cureus,2021
3. Guidelines-similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension;G Scott;Am J Obstet Gynecol,2022
4. Management of Preexisting Diabetes in Pregnancy: A Review;AS Alexopoulos;JAMA,2019
5. Pharmacokinetic studies in pregnancy.;MJ Avram;Semin Perinatol,2020
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献