Defining the minimum inhibitory concentration of 22 rifamycins in iron limited, physiologic medium against Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae clinical isolates

Author:

Lu Peggy,Alletto Francesco,Lee Bosul,Burk Elizabeth,Martinez Jasmine,Prati Fabio,Caselli EmiliaORCID,Spellberg Brad,Luna BrianORCID

Abstract

Recently, we reported rifabutin hyper-activity against Acinetobacter baumannii. We sought to characterize if any additional rifamycins (n = 22) would also display hyper-activity when tested in iron-limited media against A. baumannii, K. pneumoniae, and E. coli. MICs were determined against representative clinical isolates using the iron-limited media RPMI-1640. Only rifabutin was hyperactive against A. baumannii.

Funder

Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

Reference12 articles.

1. A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii;B Luna;Nat Microbiol,2020

2. In Vitro Activity of Rifabutin and Rifampin against Antibiotic-Resistant Acinetobacter baumannii, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae;B Lee;mSphere,2021

3. Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii;J Cheng;Antimicrob Agents Chemother,2021

4. In vitro activity of rifabutin against 293 contemporary carbapenem-resistant Acinetobacter baumannii clinical isolates and characterization of rifabutin mode of action and resistance mechanisms;V Trebosc;J Antimicrob Chemother,2020

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