Abstract
Background
In Guangxi province of China, there is a high prevalence of HIV in the general population and in men who have sex with men (MSM). However, there is still a low proportion of MSM among people living with HIV. This apparent contradiction could be due to the high proportion of potential non-disclosed MSM (pnMSM) among reported heterosexual men. We analyzed the genetic linkage of HIV specimens to address this problem aiming to (1) identify the optimal genetic distance threshold, which gave the highest number of genetic clusters, (2) document the proportion of potential non-disclosed MSM (pnMSM) among self-reported heterosexual men, and (3) determine predictors for pnMSM.
Methods
Pairwise genetic distances were computed among all samples. The genetic distance threshold giving the highest number of genetic clusters was identified. Self-reported heterosexual men were identified as belonging to the pnMSM group if they could be linked to any MSM in their cluster. Multinomial logistic regression was used to determine associated factors of being pnMSM.
Results
The optimal genetic distance threshold was 0.75% substitutions/site. Among 896 self-reported heterosexual men, the frequency (percentage and 95% confidence interval) was 62 (6.9%, 5.2–8.6%) for pnMSM, 779 (86.9%, 84.7–89.1%) for indeterminate men and 55 (6.1%, 4.5–7.7%) for potential heterosexual men, respectively. Self-reported heterosexual men who were younger, single and more educated were more likely to be pnMSM.
Conclusion
Based on these findings, there is a need to pay more attention to sexually active, young and educated self-reported heterosexual men and provide them with voluntary counselling and testing and specific HIV prevention services.
Funder
2019 PSU-Faculty of Medicine International Student Graduate Scholarships
National Natural Science Foundation of China
Ministry of Science and Technology of the people’s republic of China
Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response
Guangxi Key Laboratory of AIDS Prevention Control and Translation
Guangxi Bagui Honor Scholar and Guangxi Natural Science Foundation Project
Publisher
Public Library of Science (PLoS)
Cited by
5 articles.
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