Abstract
In industrialized countries, health care associated infections, the fourth leading cause of disease, are a major health issue. At least half of all cases of nosocomial infections are associated with medical devices. Antibacterial coatings arise as an important approach to restrict the nosocomial infection rate without side effects and the development of antibiotic resistance. Beside nosocomial infections, clot formation affects cardiovascular medical devices and central venous catheters implants. In order to reduce and prevent such infection, we develop a plasma-assisted process for the deposition of nanostructured functional coatings on flat substrates and mini catheters. Silver nanoparticles (Ag NPs) are synthesized exploiting in-flight plasma-droplet reactions and are embedded in an organic coating deposited through hexamethyldisiloxane (HMDSO) plasma assisted polymerization. Coating stability upon liquid immersion and ethylene oxide (EtO) sterilization is assessed through chemical and morphological analysis carried out by means of Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). In the perspective of future clinical application, an in vitro analysis of anti-biofilm effect has been done. Moreover, we employed a murine model of catheter-associated infection which further highlighted the performance of Ag nanostructured films in counteract biofilm formation. The anti-clot performances coupled by haemo- and cytocompatibility assays have also been performed.
Publisher
Public Library of Science (PLoS)
Reference61 articles.
1. Incidence and clinical implication of nosocomial infections associated with implantable biomaterials–catheters, ventilator-associated pneumonia, urinary tract infections;JP Guggenbichler;GMS Krankenhaushygiene Interdiszip,2011
2. Central venous catheter-related thrombosis in children and adults;D Citla Sridhar;Thromb Res,2020
3. Changing epidemiology of catheter-related bloodstream infections in neutropenic oncohematological patients;D Lendak;PLOS ONE,2021
4. Platelet Activation Polymorphisms in Ischemia;H Haybar;Cardiovasc Haematol Disord—Drug Targetsrug Targets—Cardiovasc Hematol Disord,2018
5. Antibacterial properties and toxicity from metallic nanomaterials [Corrigendum];GV Vimbela;Int J Nanomedicine,2018
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献