Abstract
Purpose
This research is a preliminary study to observe the high-risk HPV infection profile among asymptomatic women, as a basis for developing Indonesian-specific reagents and implementing a national vaccination program.
Methods
The research subjects were female employees/families of BUMN (state-owned enterprises) who underwent annual routine medical check-up. The research sample was a cervical swab which was examined using the Cobas® 6800 platform for HPV identification and INNO Lipa (Fujirebio) kit for identification of the genotype.
Results
Out of 858 cervical swab samples collected in this study, 31 samples were excluded as they had invalid results from the initial examination, so the remaining 827 samples continued this study protocol. Of those samples, 69 (8%) samples gave positive results, giving an overall HPV prevalence of 8%. Among HPV-positive samples, HPV 52 was the most common genotype (N = 15, 21.7%) found as both single-infection and multiple infections. The median age of subjects was 38 years. There were nine samples (13%) with multiple infections of two or more genotypes and seven samples (10.1%) with no specific genotype identified.
Conclusion
HPV prevalence was 8%, with HPV 52 being the most common high-risk type, making it a necessity to develop a diagnostic kit and vaccine for national vaccination program that is specific for Indonesian population which includes this genotype.
Publisher
Public Library of Science (PLoS)
Reference20 articles.
1. World Health Organization. Cervical cancer. Fact Sheet, February 2022 [Internet]. 2022 [cited 2023 Mar 3]. https://www.who.int/news- room/fact-sheets/detail/cervical-cancer
2. World Health Organization. Global strategy to accelerate the elimination of cervical cancer as a public health problem and its associated goals and targets for the period 2020–2030 [Internet]. Vol. 2, United Nations General Assembly. 2020. 1–56 p. https://www.who.int/publications/i/item/9789240014107
3. “Secondary prevention” against female HPV infection: literature review of the role of carrageenan;G Calagna;Expert review of anti-infective therapy,2020
4. Potential impact of a nonavalent HPV vaccine on HPV related low-and high-grade cervical intraepithelial lesions: A referral hospital-based study in Sicily;G Capra;Human vaccines & immunotherapeutics,2017
5. Himpunan Onkologi Ginekologi Indonesia. Pedoman Nasional Pelayanan Kedokteran Kanker Ginekologi [Internet]. 2018. https://yankes.kemkes.go.id/unduhan/fileunduhan_1610415049_651524.pdf