Abstract
IntroductionThe aim of this cohort study was to evaluate the relationship between anthropometric and body composition parameters and anti-SARS-CoV-2 IgG titers in a group of females who were vaccinated against COVID-19 with two doses of ChAdOx1 vaccine and then boosted with the BNT162b2 vaccine.Materials and methodsThe study group consisted of 63 women. Basic demographic and clinical data were collected. To assess the anti-SARS-CoV-2 immunoglobulin G titers following the vaccination, five blood draws were performed: 1) before the first dose, 2) before the second dose, 3) 14–21 days after the primary vaccination, 4) before the booster, and 5) 21 days after the booster. Blood samples were analyzed using a two-step enzymatic chemiluminescent assay. Body mass index and body composition were evaluated using bioelectrical impedance analysis. To select the most distinguishing parameters and correlations between anthropometric and body composition parameters and anti-SARS-CoV-2 IgG titers, factor analysis using the Principal Component Analysis was conducted.ResultsSixty-three females (mean age: 46.52 years) who met the inclusion criteria were enrolled. 40 of them (63.50%) participated in the post-booster follow-up. After receiving two doses of the ChAdOx1 vaccine, the study group’s anti-SARS-CoV-2 IgG titers were 67.19 ± 77.44 AU/mL (mean ± SD), whereas after receiving a heterologous mRNA booster, the level of anti-SARS-CoV-2 IgG titers was about three-times higher and amounted to 212.64 ± 146.40 AU/mL (mean ± SD). Our data shows that seropositivity, obesity, non-fat-related, and fat-related body composition parameters all had a significant effect on the level of IgG titer after a two-dose vaccination of ChAdOx1. However, only non-fat-related and fat-related body composition parameters had a significant effect on the IgG titer after booster vaccination.ConclusionCOVID-19 infection before the first dose of vaccination is not related to IgG titer after booster administration. Body composition has a significant effect on the production of anti-SARS-CoV-2 IgG after booster vaccination in females.
Funder
Silesian Park of Medical Technologies Kardio-Med Silesia in Zabrze
Medical University of Silesia in Katowice, Zabrze, Poland
Publisher
Public Library of Science (PLoS)
Reference124 articles.
1. Pneumonia of unknown cause–China. [cited 27 Jan 2023]. Available: https://www.who.int/emergencies/disease-outbreak-news/item/2020-DON229
2. Coronavirus disease 2019 (COVID-19) Situation Report—75. World Health Organization; Available: https://www.who.int/emergencies/disease-outbreak-news/item/2020-DON229
3. A global database of COVID-19 vaccinations.;E Mathieu;Nat Hum Behav,2021
4. A Review of Different Vaccines and Strategies to Combat COVID-19.;S Sabitha;Vaccines,2022
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