Abstract
In 2019, the World Health Organization declared 3 billion to be at risk of developing Crimean Congo Hemorrhagic Fever (CCHF). The causative agent of this deadly infection is CCHFV. The data related to the biology and immunology of CCHFV are rather scarce. Due to its indispensable roles in the viral life cycle, NP becomes a logical target for detailed viral immunology studies. In this study, humoral immunity to NP was investigated in CCHF survivors, as well as in immunized mice and rabbits. Abundant antibody response against NP was demonstrated both during natural infection in humans and following experimental immunizations in mice and rabbits. Also, cellular immune responses to recombinant NP (rNP) was detected in multispecies. This study represents the most comprehensive investigation on NP as an inducer of both humoral and cellular immunity in multiple hosts and proves that rNP is an excellent candidate warranting further immunological studies specifically on vaccine investigations.
Funder
TÜBİTAK
Bezmiâlem Vakif Üniversitesi
Publisher
Public Library of Science (PLoS)
Subject
Infectious Diseases,Public Health, Environmental and Occupational Health
Reference60 articles.
1. Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus.;M Zivcec;Viruses,2016
2. Subclinical infections with Crimean-Congo hemorrhagic fever virus, Turkey;H Bodur;Emerging infectious diseases,2012
3. Monitoring Crimean-Congo haemorrhagic fever virus RNA shedding in body secretions and serological status in hospitalised patients, Turkey, 2015.;D Yagci-Caglayik;Euro surveillance: bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.,2020
4. Fatal Case of Crimean-Congo Hemorrhagic Fever Caused by Reassortant Virus, Spain, 2018;A Negredo;Emerging infectious diseases,2021
5. An Unexpected Fatal CCHF Case and Management of Exposed Health Care Workers.;G Guven;International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases,2017
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