Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism

Author:

Pereira Adriana S. A.,Amaral Murilo S.ORCID,Vasconcelos Elton J. R.,Pires David S.,Asif Huma,daSilva Lucas F.,Morales-Vicente David A.,Carneiro Vitor C.,Angeli Claudia B.,Palmisano Giuseppe,Fantappie Marcelo R.,Pierce Raymond J.,Setubal João C.,Verjovski-Almeida SergioORCID

Funder

Seventh Framework Programme

FAPESP

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Public Library of Science (PLoS)

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health

Reference82 articles.

1. Human schistosomiasis;B Gryseels;Lancet,2006

2. WHO (2018) World Health Organization. Schistosomiasis. Fact sheet: acessed 18 Apr 2018.

3. Internação hospitalar e mortalidade por esquistossomose mansônica no Estado de Pernambuco, Brasil, 1992/2000;R.S. Resendes APCS;Caderno de Saúde Pública,2005

4. Brasil (2017) Guia de Vigilância em Saúde. Ministério da Saúde, Secretaria de Vigilância em Saúde Coordenação geral de desenvolvimento da epidemiologia em serviços. pp. 527–536.

5. Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria;PJ Hotez;PLoS Med,2006

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