Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted

Author:

Nguyen Thi Huyen Tram,Guedj JérémieORCID,Anglaret Xavier,Laouénan CédricORCID,Madelain Vincent,Taburet Anne-Marie,Baize Sylvain,Sissoko DaoudaORCID,Pastorino Boris,Rodallec Anne,Piorkowski Géraldine,Carazo SaraORCID,Conde Mamoudou N.,Gala Jean-LucORCID,Bore Joseph Akoi,Carbonnelle Caroline,Jacquot Frédéric,Raoul Hervé,Malvy Denis,de Lamballerie XavierORCID,Mentré France,

Publisher

Public Library of Science (PLoS)

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health

Reference19 articles.

1. World Health Organization. WHO | Ebola situation reports [Internet]. Available: http://apps.who.int/iris/bitstream/10665/208883/1/ebolasitrep_10Jun2016_eng.pdf?ua=1

2. World Health Organization. Categorization and prioritization of drugs for consideration for testing or use in patients infected with Ebola. In: Ebola treatments and interventions. 3 July 2015 [Internet]. [cited 7 Sep 2015]. Available: http://www.who.int/medicines/ebola-treatment/2015_0703TablesofEbolaDrugs.pdf?ua=1

3. Post-exposure efficacy of oral T-705 (Favipiravir) against inhalational Ebola virus infection in a mouse model;SJ Smither;Antiviral Res,2014

4. Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model;L Oestereich;Antiviral Res,2014

5. Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials;V Madelain;Clin Pharmacokinet,2016

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