KIDNEYS INVOLVEMENT INTO THE THYROID GLAND BURNING PATHOGENETIC MECHANISMS

Abstract

Background. Burn injuries considered to be the most common and severe diseases in people, positioned second place after traffic injuries. The thyroid gland, taking into account the wide range of thyroid hormones physiological activity, its structural and functional organization and morpho-functional features as well as large-scale duplicative mechanisms of regulatory feedback, is one of the first which receives the alterative thermal influence. Thyroid gland and other organs of the body dysfunction or pathological dysregulation occurs as a result of thermal exposure “triggers” systemic dysfunctions via the “vicious circle” and positive feedback mechanisms and systemic-antisystemic regulation which cannot be ignored by the majority of internal organs and organ systems resulting ion their functional disorders. We decided to test the assumptions regarding the kidneys participation in thyroid burning pathological process manifestation. Aim: to investigate the changes in lipid peroxidation and antioxidant defense in erythrocytes and kidney tissue and to investigate the kidneys functional activity throughout the thyroid gland thermal. Materials and methods. The malondialdehyde concentration and antioxidant enzymes activity - glutathione, catalase, superoxide dismutase and glutathione peroxidase - were determined in white Wistar rats’ erythrocytes and kidney homogenate 1, 3, 7, 14, 21, and 30 days after the thyroid gland burning. Diuresis was calculated in rats during induced water diuresis and both the protein and creatinine content in urine was determined during the indicated periods after thyroid gland burning Results. The significant accumulation of lipoperoxidation intermediate products and the antioxidant enzymes activity suppression in erythrocytes and in the kidney parenchyma are registered in rats during the post-burn period. The postburn period course is characterized by diuresis decrease. The urine protein level increased and the rate of protein excretion also increased in conditions of thyroid gland burning Conclusion. Significant accumulation of lipoperoxidation intermediate products and the antioxidant enzymes activity suppression in erythrocytes and in the liver parenchyma is recorded in thyroid gland burning dynamics which we consider as evidence of erythrocytes and kidney involvement in the specified pathological process mediation. The expressed renal dysfunction develops with thyroid gland thermal damage which is manifested by kidneys both excretory and filtering functions impairment. The data obtained we consider as the experimental background for kidney involvement into the thyroid gland burning pathogenetic mechanisms and the pathological dysregulation of organs and organ systems formation in these pathological conditions.