EFFECT OF INFECTIOUS FACTORS AND MORPHOLOGICAL CHANGES OF REPRODUCTIVE ORGANS ON IMPLANTATION FAILURE

Abstract

Relevance. Infertility is one of the most significant medical problems with significant demographic, economic and social consequences that affects millions of people of reproductive age. An estimated 48 to 186 million couples worldwide suffer from infertility. Most causes of infertility such as male factor, endocrine pathology and tubal factor can be diagnosed. However, there are reasons that do not lend themselves to primary identification. One of these reasons is infertility due to implantation failure. Objective: to determine the influence of anatomical, morphological and infectious factors on implantation failure during in vitro fertilization. Materials and methods. A prospective, open, controlled study of 106 infertile patients who underwent examination and treatment using assisted reproductive technologies was conducted in the period «September 2019 – February 2021». All patients were divided into 2 groups. Control group 54 entered patients. The main group included 52 patients who additionally underwent complex therapy with aspirin, heparin and intravenous immunoglobulins. One-factor and six-factor models of logistic regression of the risk of implantation failure have been analyzed. Results. The analysis revealed an increased risk of implantation failure in the presence of previous ureaplasma infection (p = 0.029), OR = 3.68 (95% CI 1.14-11.9). The risk also increases (p = 0.012), OR = 4.36 (95% CI 1.38-13.8) in the presence of an anomaly of the uterine cavity and after laparoscopic surgery (p = 0.015), OR = 3.53 (95% CI 1.28-9.78). Conclusions. Based on obtained data, presence of pathology of the pelvic organs and/or previous infections do not have an isolated effect on implantation failure. The risk of implantation failure should be assessed with other factors that affect the implantation process.