ASSOCIATION BETWEEN OF ANTIOXIDANT PROTECTION WITH CHRONOLOGICAL AND BIOLOGICAL AGE IN PATIENTS WITH ARTERIAL HYPERTENSION

Abstract

Relevance. The study is relevant due to the increase in the prevalence of arterial hypertension (AH) with age, as well as the presence of common developmental mechanism with aging processes, that is a violation of antioxidant protection. Given the changes in the antioxidant state with age, studying their relationship with biological age (BA) may be useful in this category of patients. Objective: to study changes in antioxidant status in AH patients of various age categories and their relationship with calendar age (CA) and BA, calculated using two outpatient methods. Materials and methods. The study included 96 patients with an average age of 50.8 ± 14.3 years (53.1% of women), who were divided into 2 groups: the main group (n=71) – patients with AH degrees 1-2 stages 1-2 with low and moderate cardiovascular risk, controls (n=25) – healthy patients randomized by age and sex. Patients of the main group were divided into subgroups depending on age: 25-44 years (n=21), 45-59 years (n=25) and over 60 years (n=25). Markers of antioxidant protection: total antioxidant capacity (TAC) and total antioxidant activity (TAA) were determined in all patients. BA was calculated using the method of A. G. Gorelkin and B. B. Pinkhasov (BA1) and V.P. Voitenko’s method (BA2 ). Results. Patients of the main group had higher BA1 (p=0.024), BV2 (p=0.004), greater weight (p=0.010), body mass index (p=0.008), waist circumference (p=0.003). Also, there were tendencies towards an increase in TAC and a decrease in TAA in AH patients, compared with controls, although the differences were not significant. Correlation was found between CA and TAC (r=0.422; p=0.032) in the controls, and in the main group there was an association between CA and TAA (r=-0.357; p=0.003), the strength of which increased in young patients (r=-0.412; p=0.037). When comparing the levels of antioxidant state markers in AH patients depending on CA and BA, there was no significant difference in TAC levels, while TAA levels were the lowest in the group of patients aged 25-44 (p<0.05). After grouping patients depending on BA, there was an even more noticeable decrease in TAA in patients over 60 years old compared to controls. Conclusions. The associations between CA and the level of TAC in the controls and TAA in the main group were demonstrated. The relationship of these parameters with BA was observed only in patients with AH, which may indicate the effectiveness of BA evaluating using the methods of A. G. Gorelkin, B. B. Pinkhasov, and V. P. Voitenko for assessing the aging rate in AH patients. In young and elderly patients, the determination of TAA levels may be of greater diagnostic value than the determination of TAC. The nature of TAA changes in AH patients of the middle age, is different from patients of young and old age, which requires further study, taking into account other possible factors.