Effect of Bay leaf (Laurus nobilis L.) and its isolated (flavonoids and glycosides) on the lipids profile in the local Iraqi female rabbits

Abstract

The present study aimed to explain the effect of Bay leaf and its isolated flavonoids and glycosides on the levels of TC, TG, HDL-C, LDL-C and VLDL-C in the local Iraqi female rabbits. Isolation of flavonoids and glycosides from Bay leaf were carried out, the study design included four groups (n=6): Control group-C fed with standard pellet diet; group1-G1 orally administrated daily dose 100 mg/ml/kg of Bay leaf crude for 30 days; group2-G2 orally administrated daily dose 50 mg/ml/kg of isolated flavonoids for 30 days; group3-G3 orally administrated daily dose 12.5 mg/ml/kg of isolated glycosides for 30 days. TC, TG and HDL-C were determined by enzymatic colorimetric method. The results showed that oral administration of Bay leaf and its isolated flavonoids and glycosides reduced levels of TC, TG, LDL-C and VLDL-C compared to control, therefore Bay leaf useful agent in reducing hyperlipidemia.