Relationship between serum Prostate Specific Antigen (PSA) in women with polycystic ovary syndrome and some reproductive hormones in Kirkuk city

Abstract

PCOS is one of the most common endocrine disorders among women between 12 and 45 years of age, affecting 5-10% of women. The patients were included in the current study based on the criteria of Rotterdam in the diagnosis of polycystic ovarian syndrome with at least two of the following three criteria: menstrual cycle disorder, chemical criteria for high levels of androgen, detection of polycystic ovary using ultrasound (10 or more cysts of 2-10 mm in diameter). Sixty (60) patients were diagnosed with the syndrome and 30 healthy women were considered as control groups aged between 16 and 46 years.A number of criteria have been adopted to exclude patients who have had previous ovarian surgery as well as women taking contraceptives, steroids and herbal medicines that affect ovarian function for at least two months. The study was conducted at the Azadi Teaching Hospital in the city of Kirkuk for the period from October 2016 to February 2017. Blood collected for all participants on the second or third day of the menstrual cycle. Body mass index (BMI) was calculated and prostate specific antigen (PSA) level and the level of sex hormones such as Anti-mullarian hormone(AMH),Luteinizing hormone(LH),Follicular stimulating hormone(FSH),Testosterone hormone(T) as well as Luteinizing hormone/Follicular stimulating hormone(LH / FSH) ratio were determined. The relationship between PSA and all studied variables was investigated after dividing the study sample into three age groups A (16-25), B (26-35), and C (36-45) years. Each age group included 30 patients with PCOS and 10 women as a control group).The results showed a significant increase (p <0.05) in the level of the PSA, AMH, LH, T and LH / FSH ratio, conversely the level of FSH was significantly reduced (p <0.05) when comparing women patientswith the control group. Correlation results showed a positive correlation between the PSA level and the values of all the studied variables except for FSH, which was inversely correlated with serum PSA in PCOS patients and for most age groups except for category C where AMH showed a negative correlation with PSA. The results also indicated a significant correlation between PSA and T, LH, and LH / FSH ratio for all ages groups. PSA can therefore be considered as a biochemical marker for androgen activity changes in patients with PCOS