Effect of Ganoderma Fungi and Spirulina Alga in The Liver Tissue of Diabetic Mice Developed with Aloxane and Lead-Induced Anemia

Abstract

The study was conducted on male mice (Albino mice), which ranged in age from (2-3) months and weights (25 - 30) g. The experiment was conducted in the General Company for the manufacture of medicines and medical supplies - Samarra. And for the period from the beginning of October 2017 to the end of March 2018, Used 42 animals were distributed in seven groups, each containing 6 animals, to determine the effects of both gannoderma and spirulina in laboratory mice induced by diabetes mellitus with a Aloxan at 150 mg / kg Bw. In laboratory mice with anemia with lead acetate of 50 mg / Kg body weight for 30 days (except control group) At the end of the 30-day feeding period. control group on the regular diet. control group infected diabetes and drugs on the regular diet. The group of diabetic animals treated with ganoderma fungi powder (47 mg / kg body weight). The group of diabetic animals and the treatment of spirulina algae powder (33 mg / kg body weight). group of animals infected with anemia and spores on the regular diet and water containing lead acetate Group of infected animals and treated with lead acetate + Ganoderma fungi powder (47 mg / kg body weight). Group of infected animals and treated with lead acetate + Spirulina algae powder (33 mg / kg body weight).  Histological changes were observed in the Livre tissue: The results of the study of tissues in the group of animals treated with Alloxnesan damage to the overall liver tissue in the form of hepatocytes and hydrolysis and the expansion of the Sinusiod. In the treatment of diabetic animals with ganoderma and spirulina algae, there was improvement in the overall liver tissue in terms of normal hepatocytes, absence of congestion, and normal Sinusiod.  the group treated with anemia and treated with lead acetate, we also notice significant damage to the liver tissue. When treated with lead acetate + gannoderma, and spirulina, we did not notice any improvement in liver tissue.