Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target-Reference-Cited by-同舟云学术

Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target

Published:2011-03-08 Issue: Volume:2011 Page:1-5
ISSN:2090-0414
Container-title:Enzyme Research
language:en
Short-container-title:Enzyme Research

Author:

Jankowski Maciej¹²

Affiliation:

1. Department of Therapy Monitoring and Pharmacogenetics, Medical University of Gdańsk, Debinki 7, 80-211 Gdańsk, Poland

2. Laboratory of Molecular and Cellular Nephrology, Mossakowski Medical Research Center, Polish Academy of Sciences, 80-211 Gdańsk, Poland

Abstract

Autotaxin (ATX) is an extracellular lysophospholipase D (lysoPLD) released from normal cells and cancer cells. Activity of ATX is detected in various biological fluids. The lysophosphatidic acid (LPA) is the main product of ATX. LPA acting through specific G protein-coupled receptors (LPA1-LPA6) affects immunological response, normal development, and malignant tumors' formation and progression. In this review, the impact of autotoxin on biology of melanoma cells and potential treatment is discussed.

Publisher

Hindawi Limited

Subject

Molecular Biology,Biochemistry

Link

http://downloads.hindawi.com/archive/2011/194857.pdf

Reference53 articles.

1. NPP-type ectophosphodiesterases: unity in diversity

2. Autotaxin is an N linked glycoprotein but the sugar moieties are not needed for its stimulation of cellular motility

3. Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D

4. Autotaxin (ATX): A multi-functional and multi-modular protein possessing enzymatic lysoPLD activity and matricellular properties

5. Autotaxin--an LPA producing enzyme with diverse functions

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