Affiliation:
1. Unit of Metabolic Bone Diseases, Department of Internal Medicine, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Abstract
MicroRNAs (miRNAs) are endogenous noncoding RNAs that negatively regulate gene expression by binding the 3′noncoding region of the messenger RNA targets inducing their cleavage or blocking the protein translation. They play important roles in multiple biological and metabolic processes, including developmental timing, signal transduction, and cell maintenance and differentiation. Their deregulation can predispose to diseases and cancer. miRNA expression has been demonstrated to be deregulated in many types of human tumors, including thyroid cancers, and could be responsible for tumor initiation and progression. In this paper we reviewed the available data on miRNA deregulation in different thyroid tumors and describe the putative role of miRNA in thyroid cancer development.
Funder
Fondazione Ente Cassa di Risparmio di Firenze
Subject
Endocrinology, Diabetes and Metabolism
Cited by
67 articles.
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